Pilot Randomized Controlled Trial of an Exercise Program Requiring Minimal In-person Visits for Youth With...

Pilot Randomized Controlled Trial of an Exercise Program Requiring Minimal In-person Visits for Youth With..., Objective: To evaluate feasibility and acceptability of a sub-threshold exercise program with minimal in-person visits to treat youth with persistent sport-related concussion, and explore efficacy for improving concussive symptoms, health-related quality of life and fear-avoidance., Objective: To evaluate feasibility and acceptability of a sub-threshold exercise program with minimal in-person visits to treat youth with persistent sport-related concussion, and explore efficacy for improving concussive symptoms, health-related quality of life and fear-avoidance.

Study design: We conducted a pilot randomized controlled trial comparing a 6-week sub-threshold exercise program requiring only two in-person visits to active control (stretching) for 12-18 year old youth with persistent sport-related concussion. We measured moderate-to-vigorous physical activity pre- and post-intervention using accelerometry, and increased goals weekly via phone contact. We examined feasibility and acceptability using qualitative interviews. We used exponential regression to model differences in trajectory of concussive symptoms by experimental group, and linear regression to model differences in trajectory of health-related quality of life and fear-avoidance of pain by experimental group.

Results: 32 subjects randomized, 30 completed the study (n=11 control, n=19 intervention), 57% female. Youth and parents reported enjoying participating in the study and appreciated the structure and support, as well as the minimal in-person visits. Exponential regression modeling indicated that concussive symptoms declined more rapidly in intervention youth than control (p=0.02). Health-related quality of life and fear-avoidance of pain improved over time, but were not significantly different by group.

Conclusions: This study indicates feasibility and potential benefit of a 6 week subthreshold exercise program with minimal in-person visits for youth with persistent concussion. Potential factors that may play a role in improvement such as fear-avoidance deserve further study., admin,

Intellectual and Developmental Disabilities Research Centers: 50 Years of Scientific Accomplishments

Intellectual and Developmental Disabilities Research Centers: 50 Years of Scientific Accomplishments, Abstract Progress in addressing the origins of intellectual and developmental disabilities accelerated with the establishment 50 years ago of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health and associated Intellectual and Developmental Disabilities Research Centers.,

Abstract


Progress in addressing the origins of intellectual and developmental disabilities accelerated with the establishment 50 years ago of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health and associated Intellectual and Developmental Disabilities Research Centers. Investigators at these Centers have made seminal contributions to understand human brain and behavioral development, and to define mechanisms and treatments of disorders of the developing brain.


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High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs

High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs, Reward outcomes depend on the stimulation protocol used to activate nucleus accumbens medium spiny neuron (MSN) subtypes. In this issue of Neuron, Francis et al. demonstrate rebalanced MSN subtype excitation driven by high-frequency stimulation and substance P release., Reward outcomes depend on the stimulation protocol used to activate nucleus accumbens medium spiny neuron (MSN) subtypes. In this issue of Neuron, Francis et al. demonstrate rebalanced MSN subtype excitation driven by high-frequency stimulation and substance P release., admin,

Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration

Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration, Hertz et al. identify the neuronally enriched protein RUFY3 as a key regulator downstream of (or in parallel to) caspase-3 in axon degeneration. RUFY3 is dephosphorylated and cleaved during degeneration. RUFY3 may provide a neuron-specific control point for neurons to locally control axon degeneration., Hertz et al. identify the neuronally enriched protein RUFY3 as a key regulator downstream of (or in parallel to) caspase-3 in axon degeneration. RUFY3 is dephosphorylated and cleaved during degeneration. RUFY3 may provide a neuron-specific control point for neurons to locally control axon degeneration., admin,

You shall not pass! Gut bacteria can convert levodopa to dopamine

You shall not pass! Gut bacteria can convert levodopa to dopamine, , , admin,

Disorders of the spinal cord and roots

Disorders of the spinal cord and roots, I, Introduction

The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Prevalence and pathophysiology of post-prandial migraine in patients with functional dyspepsia

    Prevalence and pathophysiology of post-prandial migraine in patients with functional dyspepsia, Cephalalgia, Ahead of Print. BackgroundMigraine is a condition frequently associated with gastrointestinal disorders. Previous reports have shown the relationship between irritable bowel syndrome and migraine, but no data are yet available in patients with functional dyspepsia. We therefore evaluated whether alteration of gastric sensorimotor activity may be related to migraine., Cephalalgia, Ahead of Print.
    BackgroundMigraine is a condition frequently associated with gastrointestinal disorders. Previous reports have shown the relationship between irritable bowel syndrome and migraine, but no data are yet available in patients with functional dyspepsia. We therefore evaluated whether alteration of gastric sensorimotor activity may be related to migraine.MethodsSixty patients affected by functional dyspepsia, 38 with postprandial distress syndrome and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated.ResultsIn epigastric pain syndrome, 12/22 (54%) patients suffered from migraine and this condition was never correlated with meal ingestion. In postprandial distress syndrome patients, 29/38 (76%) suffered from migraine, in 26/29 (89%) its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold (r = −0.73; p < 0.001). In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine. In patients with moderate to severe migraine, gastric accommodation, sensitivity thresholds and gastric emptying time were similar to patients with mild or no migraine.ConclusionsIn patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. On clinical grounds, it is associated with an increased severity of fullness and early satiation and, on pathophysiological grounds, it seems correlated with postprandial hypersensitivity., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,