Disorders of the spinal cord and roots

Disorders of the spinal cord and roots, I, Introduction

The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Education in patients with psychogenic nonepileptic seizures

    Psychogenic nonepileptic seizures (PNES) consist of paroxysmal changes in responsiveness, movements, or behavior that seemingly resemble epileptic seizures, but lack a neurobiological origin similar to epileptic seizures and are not associated with electrophysiological epileptic changes [1]. Learning problems are common among patients with PNES; however, they are often undiagnosed and untreated [2,3]. Intrinsic brain connectivity abnormalities and dysfunctions are being suggested in the pathophysiology of PNES [4], therefore, it is not irrational to presume that education and PNES may have associations.

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    Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of Intracerebral Hemorrhage In Vivo

    Objective: The exact role of nuclear factor-kappaB (NF-κB) in intracerebral hemorrhage (ICH) is still unclear to date. The aim of the present study is to clarify the activation of NF-κB and the role of its subunits in inflammatory response and cell death after ICH. Methods: The model of ICH rats was made, and at preset time points after operation, as well as rats in the control and sham groups, the ipsilateral striatum and tissue around was obtained for detection of NF-κB activation, cell death, and expression of interleukin-1β, tumor necrosis factor-α, Caspase-3, Bcl-2, and NF-κB subunits.

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    Sleep Apnea-Predictor of Functional Outcome in Acute Ischemic Stroke

    Background: Sleep apnea is increasingly being recognized as 1 of the important, modifiable risk factors of stroke and cardiovascular diseases. Sleep apnea is thought to impair the functional recovery following stroke. Hence, we evaluated the patients with acute ischemic stroke for prevalence of sleep apnea and compared the functional outcomes of patients with and without sleep apnea, at 3rd month of acute ischemic stroke. Method: This study was conducted in Kasturba Medical College (KMC) hospital, Manipal, India, between May 2015 and August 2016.

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    Education in patients with psychogenic nonepileptic seizures

    Education in patients with psychogenic nonepileptic seizures, Psychogenic nonepileptic seizures (PNES) consist of paroxysmal changes in responsiveness, movements, or behavior that seemingly resemble epileptic seizures, but lack a neurobiological origin similar to epileptic seizures and are not associated with electrophysiological epileptic changes [1]., Psychogenic nonepileptic seizures (PNES) consist of paroxysmal changes in responsiveness, movements, or behavior that seemingly resemble epileptic seizures, but lack a neurobiological origin similar to epileptic seizures and are not associated with electrophysiological epileptic changes [1]. Learning problems are common among patients with PNES; however, they are often undiagnosed and untreated [2,3]. Intrinsic brain connectivity abnormalities and dysfunctions are being suggested in the pathophysiology of PNES [4], therefore, it is not irrational to presume that education and PNES may have associations., admin,

    Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of...

    Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of..., Objective: The exact role of nuclear factor-kappaB (NF-κB) in intracerebral hemorrhage (ICH) is still unclear to date. The aim of the present study is to clarify the activation of NF-κB and the role of its subunits in inflammatory response and cell death after ICH., Objective: The exact role of nuclear factor-kappaB (NF-κB) in intracerebral hemorrhage (ICH) is still unclear to date. The aim of the present study is to clarify the activation of NF-κB and the role of its subunits in inflammatory response and cell death after ICH. Methods: The model of ICH rats was made, and at preset time points after operation, as well as rats in the control and sham groups, the ipsilateral striatum and tissue around was obtained for detection of NF-κB activation, cell death, and expression of interleukin-1β, tumor necrosis factor-α, Caspase-3, Bcl-2, and NF-κB subunits., admin,

    Sleep Apnea-Predictor of Functional Outcome in Acute Ischemic Stroke

    Sleep Apnea-Predictor of Functional Outcome in Acute Ischemic Stroke, Background: Sleep apnea is increasingly being recognized as 1 of the important, modifiable risk factors of stroke and cardiovascular diseases. Sleep apnea is thought to impair the functional recovery following stroke., Background: Sleep apnea is increasingly being recognized as 1 of the important, modifiable risk factors of stroke and cardiovascular diseases. Sleep apnea is thought to impair the functional recovery following stroke. Hence, we evaluated the patients with acute ischemic stroke for prevalence of sleep apnea and compared the functional outcomes of patients with and without sleep apnea, at 3rd month of acute ischemic stroke. Method: This study was conducted in Kasturba Medical College (KMC) hospital, Manipal, India, between May 2015 and August 2016., admin,

    Reevaluating the pathogenicity of the mutation c.1194 +5 G>A in GAA gene by functional analysis of RNA

    Pompe disease or glycogen storage disease type II, (OMIM: 232300), is an autosomal recessive inherited disorder caused by mutations in GAA gene. It is located in the long arm of chromosome 17 (Chromosome 17: 80,101,556-80,119,879 forward strand (GRCh38:CM000679.2)) and includes 20 exons [1]. GAA encodes the lysosomal acid alpha glucosidase (acid maltase; EC. 3.2.10.20), the enzyme responsible of the intra-lysosomal glycogen hydrolysis. GAA deficiency results in progressive accumulation of glycogen in the lysosomes.

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    Reevaluating the pathogenicity of the mutation c.1194 +5 G>A in GAA gene by functional analysis of RNA

    Reevaluating the pathogenicity of the mutation c.1194 +5 G>A in GAA gene by functional analysis of RNA, Pompe disease or glycogen storage disease type II, (OMIM: 232300), is an autosomal recessive inherited disorder caused by mutations in GAA gene. It is located in the long arm of chromosome 17 (Chromosome 17: 80,101,556-80,119,879 forward strand (GRCh38:CM000679.2)) and includes 20 exons [1]. GAA encodes the lysosomal acid alpha glucosidase (acid maltase; EC. 3.2.10., Pompe disease or glycogen storage disease type II, (OMIM: 232300), is an autosomal recessive inherited disorder caused by mutations in GAA gene. It is located in the long arm of chromosome 17 (Chromosome 17: 80,101,556-80,119,879 forward strand (GRCh38:CM000679.2)) and includes 20 exons [1]. GAA encodes the lysosomal acid alpha glucosidase (acid maltase; EC. 3.2.10.20), the enzyme responsible of the intra-lysosomal glycogen hydrolysis. GAA deficiency results in progressive accumulation of glycogen in the lysosomes., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    Disorders of the spinal cord and roots

    Disorders of the spinal cord and roots, I, Introduction

    The distinctive patterns of myelopathy (disorder of the spinal cord) and radiculopathy (disorder of spinal roots) are a direct consequence of the striking anatomy of the spinal cord:

  • its near cylindrical, segmental structure of great length (42–45 cm in adults)

  • the marked proximity of ascending and descending long tracts within the confines of a narrow cross sectional area (the maximum circumference of the cervical enlargement of the cord is approximately 38 mm)

  • enclosure by meninges and vertebral column

  • vulnerable blood supply.

  • Having established that a patient's clinical presentation localises to the spinal cord and/or roots, clues to the pathological diagnosis emerge from the timing of the symptoms (table 1), as is usually the case in neurology.

    Neuroanatomy and specific syndromesSpinal cord

    The relationships of the white matter tracts to one another and to the..., admin,

    CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration

    Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy

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    CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration

    CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration, Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy, Marc Pawlitzki, Stefanie Schreiber, Daniel Bittner, Julia Kreipe, Frank Leypoldt, Klemens Rupprecht, Roxana O. Carare, Sven G. Meuth, Stefan Vielhaber, Peter Körtvélyessy, admin,

    Corrigendum

    Multiple Sclerosis Journal, Ahead of Print.

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    Observatoire Français de la Sclérose en Plaques (OFSEP): A unique multimodal nationwide MS registry in France

    Multiple Sclerosis Journal, Ahead of Print.

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