Neuromyelitis Optica (Devic's Disease)

Diagnosis requires all absolute criteria and one major supportive criterion or two minor supportive criteria
Absolute criteria:

1. Optic neuritis
2. Acute myelitis
3. No evidence of clinical disease outside of the optic nerve or spinal cord

Major supportive criteria:

1. Negative brain MRI at onset (does not meet criteria for multiple sclerosis)
2. Spinal cord MRI with signal abnormality extending over >/=3 vertebral segments
3. CSF pleocytosis of >50 WBC/mm3 or >5 PMNs/mm3

Minor supportive criteria:

1. Bilateral optic neuritis
2. Severe optic neuritis with fixed visual acuity worse than 20/200 in at least one eye
3. Severe, fixed, attack-related weakness (MRC </=2) in one or more limbs