Prospective studies with standardized evaluations provide one of the strongest methodologies for studying the progression of neuromuscular diseases and constructing clinical development plan to evaluate new therapies. Drop-out is a major methodological problem of longitudinal studies. It may represent an attrition bias and lead to erroneous conclusions if participants who stay in a study differ from those who dropped out. Here, we present drop-out rate and reasons for dropping-out in prospective studies in neuromuscular diseases and we study predictive factors.
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