Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors

Blanco-Suarez et al. identify that synapse maturation is not intrinsic to neurons but is regulated by neighboring astrocytes. They demonstrate that astrocyte-secreted Chrdl1 increases GluA2 AMPA receptor levels at synapses, inducing synapse maturation and inhibiting plasticity.