Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

Litvinchuk et al. show that complement C3aR plays a critical role in mediating immune homeostasis and tau pathology. The identification of a conserved C3aR network and crosstalk between complement signaling with STAT3 activation reveal novel pathogenic and therapeutic insights.