Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of...

Bimodal Distribution of Nuclear Factor-κB Activation and Expression of Subunits in Experimental Models of..., Objective: The exact role of nuclear factor-kappaB (NF-κB) in intracerebral hemorrhage (ICH) is still unclear to date. The aim of the present study is to clarify the activation of NF-κB and the role of its subunits in inflammatory response and cell death after ICH., Objective: The exact role of nuclear factor-kappaB (NF-κB) in intracerebral hemorrhage (ICH) is still unclear to date. The aim of the present study is to clarify the activation of NF-κB and the role of its subunits in inflammatory response and cell death after ICH. Methods: The model of ICH rats was made, and at preset time points after operation, as well as rats in the control and sham groups, the ipsilateral striatum and tissue around was obtained for detection of NF-κB activation, cell death, and expression of interleukin-1β, tumor necrosis factor-α, Caspase-3, Bcl-2, and NF-κB subunits., admin,