Defining the Functional Role of NaV1.7 in Human Nociception

Defining the Functional Role of NaV1.7 in Human Nociception, Gene mutations associated with painless phenotypes offer great insight for analgesic development. Using a multi-modal approach, McDermott et al. show that mutations in the voltage-gated sodium channel NaV1.7 cause congenital insensitivity to pain due to a lack of functional nociceptors., Gene mutations associated with painless phenotypes offer great insight for analgesic development. Using a multi-modal approach, McDermott et al. show that mutations in the voltage-gated sodium channel NaV1.7 cause congenital insensitivity to pain due to a lack of functional nociceptors., admin,