Mitochondrial DNA depletion in sporadic inclusion body myositis

Mitochondrial DNA depletion in sporadic inclusion body myositis, Sporadic inclusion body myositis (sIBM) is a late-onset muscle disease of unknown aetiology [1]. Patients manifest slowly progressive weakness and atrophy that characteristically affects specific muscle groups[1]. The disorder is considered the most common acquired myopathy in the middle-aged and elderly [2] with estimates of prevelance between 3.3 - 5.1 per 100,000 [2, 3]., Sporadic inclusion body myositis (sIBM) is a late-onset muscle disease of unknown aetiology [1]. Patients manifest slowly progressive weakness and atrophy that characteristically affects specific muscle groups[1]. The disorder is considered the most common acquired myopathy in the middle-aged and elderly [2] with estimates of prevelance between 3.3 - 5.1 per 100,000 [2, 3]. Although classified with the inflammatory myopathies, immunomodulatory treatments have been disappointing in controlling disease progression., admin,