Intravenous use of valproic acid in status epilepticus is associated with high risk of hyperammonemia

Intravenous use of valproic acid in status epilepticus is associated with high risk of hyperammonemia, Status epilepticus (SE) is a neurological emergency with significant morbidity and mortality [1] and requires immediate treatment. In 2012 a committee from the Neurocritical Care Society published expert consensus guidelines [2], but there is a severe lack of double-blinded randomized controlled studies of the treatment of SE., Status epilepticus (SE) is a neurological emergency with significant morbidity and mortality [1] and requires immediate treatment. In 2012 a committee from the Neurocritical Care Society published expert consensus guidelines [2], but there is a severe lack of double-blinded randomized controlled studies of the treatment of SE. Experts agree that benzodiazepines should be the agent of choice for emergent initial treatment [2]. Phenytoin, lorazepam and phenobarbital have been extensively used for this indication for many years, based largely on the evidence derived from the Veterans Affairs Cooperative Trial [3]., admin,