Sex-specific Association of Matrix Metalloproteinases with Secondary Injury and Outcomes after Intracerebral...

Sex-specific Association of Matrix Metalloproteinases with Secondary Injury and Outcomes after Intracerebral..., Intracerebral hemorrhage affects approximately 2million individuals per year. While the incidence is roughly equal in men and women, few studies have examined the influence of sex on secondary injury and associated long-term functional outcomes. Matrix metalloproteinases (MMPs) promote vessel rupture and worsen outcomes by potentiating blood-brain barrier breakdown after injury., Intracerebral hemorrhage affects approximately 2million individuals per year. While the incidence is roughly equal in men and women, few studies have examined the influence of sex on secondary injury and associated long-term functional outcomes. Matrix metalloproteinases (MMPs) promote vessel rupture and worsen outcomes by potentiating blood-brain barrier breakdown after injury. We hypothesized that different MMP isoform levels would be predictive of injury severity, secondary injury, and long-term functional outcomes in males and females, respectively., admin,