Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates...

Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates..., Meda et al. show that in chronic pain states, mediodorsal thalamic (MD) inputs to the anterior cingulate cortex (ACC) undergo pathway-specific changes. As a result, MD-ACC inputs suppress the activity of many subcortically projecting ACC neurons, thereby driving negative pain-related affect., Meda et al. show that in chronic pain states, mediodorsal thalamic (MD) inputs to the anterior cingulate cortex (ACC) undergo pathway-specific changes. As a result, MD-ACC inputs suppress the activity of many subcortically projecting ACC neurons, thereby driving negative pain-related affect., admin,