Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons, Ibata et al. find that Cbln1 is released from lysosomes by neuronal activity and accumulated at axonal boutons of cerebellar granule cells. Co-release of Cbln1 and lysosomal enzymes may serve as a new mechanism of activity-dependent coordinated synapse modification., Ibata et al. find that Cbln1 is released from lysosomes by neuronal activity and accumulated at axonal boutons of cerebellar granule cells. Co-release of Cbln1 and lysosomal enzymes may serve as a new mechanism of activity-dependent coordinated synapse modification., admin,