Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon...

Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon..., Ferent et al. elucidate how the Shh receptor Boc works together with Ptch1 to transduce the Shh signal in axon guidance. They demonstrate that Numb-mediated internalization of Boc is required for Ptch1 internalization, activation of signaling, and Shh-mediated axon guidance., Ferent et al. elucidate how the Shh receptor Boc works together with Ptch1 to transduce the Shh signal in axon guidance. They demonstrate that Numb-mediated internalization of Boc is required for Ptch1 internalization, activation of signaling, and Shh-mediated axon guidance., admin,