Trait Conscientiousness predicts rate of brain atrophy in multiple sclerosis, Multiple Sclerosis Journal, Ahead of Print. Background:Conscientiousness is a core personality trait with favorable prognosis in neuropsychiatric disease.Objective:We aimed to determine whether baseline Conscientiousness predicts future brain atrophy in multiple sclerosis (MS) after accounting for demographic and basic clinical characteristics., Multiple Sclerosis Journal, Ahead of Print.
Background:Conscientiousness is a core personality trait with favorable prognosis in neuropsychiatric disease.Objective:We aimed to determine whether baseline Conscientiousness predicts future brain atrophy in multiple sclerosis (MS) after accounting for demographic and basic clinical characteristics.Methods:Trait Conscientiousness, clinical features, and Expanded Disability Status Scale (EDSS) were obtained at baseline. Lateral ventricle volume (LVV) was measured longitudinally. In a retrospective general linear mixed effects model, data from 424 patients were analyzed (mean 6 time-points, up to 15 years).Results/Conclusion:We observed significant age and Conscientiousness by time-from-baseline interactions indicating that younger age and higher Conscientiousness are associated with reduced progression of brain atrophy., admin,
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