Annals of Neurology: Volume 86, Number 4, October 2019

Annals of Neurology: Volume 86, Number 4, October 2019, A fluorescence photomicrograph (ultramicroscopy) demonstrating cerebral blood vessels (red) and Abeta amyloid (green) in the cerebral cortex of a transgenic mouse with the APPDutch mutation in the amyloid precursor protein. Vascular Abeta deposition started in large superficial arteries with few affected small penetrating vessels.,

A fluorescence photomicrograph (ultramicroscopy) demonstrating cerebral blood vessels (red) and Abeta amyloid (green) in the cerebral cortex of a transgenic mouse with the APPDutch mutation in the amyloid precursor protein. Vascular Abeta deposition started in large superficial arteries with few affected small penetrating vessels. Early treatment with beta‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) inhibitor prevented progression. See Schelle et al., pages 561–571, in this
issue. ANN NEUROL 2019;86:1–1

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