Abstract
It is currently unclear whether the glymphatic system, a brain‐wide interstitial fluid‐cerebrospinal fluid exchange as described in rodents, exist in humans. Focal blood‐brain barrier disruption using MR‐guided focused ultrasound allows parenchymal penetration of gadobutrol contrast, creating an opportunity to study the glymphatics in vivo noninvasively. We describe patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrounding large veins draining towards the dural sinuses on FLAIR in subjects with Alzheimer's disease and amyotrophic lateral sclerosis. This first evidence suggests glymphatic efflux persist in humans, and its relevance to proteinopathies and drug delivery is discussed.
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