Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling, Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control., Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control., admin,