ABSTRACT
Objective
Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in‐situ brain physiology, this study assesses regional variations of electroencephalographic sleep activity and creates the first atlas of human sleep using recordings from the first sleep cycle.
Methods
Intracerebral electroencephalographic recordings with channels displaying physiological activity from non‐lesional tissue were selected from 91 patients of three tertiary epilepsy centers. Sections during non‐rapid eye movement sleep (N2, N3) and rapid eye movement sleep (R) were selected from the first sleep cycle for oscillatory and non‐oscillatory signal analysis. Results of 1468 channels were grouped into 38 regions covering all cortical areas.
Results
We found regional differences in the distribution of sleep transients and spectral content, during all sleep stages. There was a caudo‐rostral gradient with more slow frequencies and fewer spindles in temporo‐parieto‐occipital than in frontal cortex. Moreover, deep‐seated structures showed spectral peaks differing from the baseline electroencephalogram. The regions with >60% of channels presenting significant rhythmic activity were either mesial or temporal basal structures that contribute minimally to the scalp EEG. Finally, during deeper sleep stages, electroencephalographic analysis revealed a more homogeneous spatial distribution, with increased coupling between high and low frequencies.
Interpretation
This study provides a better understanding of the regional variability of sleep, and establishes a baseline for human sleep in all cortical regions during the first sleep cycle. Furthermore, the open‐access atlas will be a unique resource for research (https://mni‐open‐ieegatlas.research.mcgill.ca).
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