Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD...

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD..., Ortega, Daley, et al. use proteome-wide nucleocytoplasmic analysis to identify localization alterations caused by repeat expansion mutations associated with neurodegeneration. The C9orf72-ALS/FTD mutation affects proteins involved in RNA and protein metabolism and disrupts the balance between NMD and translation mediated by eRF1., Ortega, Daley, et al. use proteome-wide nucleocytoplasmic analysis to identify localization alterations caused by repeat expansion mutations associated with neurodegeneration. The C9orf72-ALS/FTD mutation affects proteins involved in RNA and protein metabolism and disrupts the balance between NMD and translation mediated by eRF1., admin,