Primary age‐related tauopathy (part) in the general autopsy setting: not just a disease of the elderly

Primary age‐related tauopathy (part) in the general autopsy setting: not just a disease of the elderly, Abstract Primary age‐related tauopathy (PART) is an entity recently introduced in an effort to clarify a common finding of neurofibrillary tangles (NFT) consistent with Alzheimer’s disease (AD), in a restricted distribution, and in the absence of beta amyloid (a‐beta, Ab) plaques at time of autopsy (4).,

Abstract

Primary age‐related tauopathy (PART) is an entity recently introduced in an effort to clarify a common finding of neurofibrillary tangles (NFT) consistent with Alzheimer’s disease (AD), in a restricted distribution, and in the absence of beta amyloid (a‐beta, Ab) plaques at time of autopsy (4). Subsequent studies have suggested that individuals with the pathologic findings of PART commonly have less clinically significant symptoms of dementia during life, as well as pathologic presentation later in life compared to AD, and have suggested an average age of death in the 9^th decade of life as compared to the 8^th decade of life with AD (2, 6, 9). It has been suggested that, in patients with PART, this manifests often as a milder clinical course when compared to those with AD.

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